Genetics and regulatory impact of alternative polyadenylation in human B-lymphoblastoid cells.

ABSTRACT: Gene expression varies widely between individuals of a population, and regulatory change can underlie phenotypes of evolutionary and biomedical relevance. A key question in the field is how DNA sequence variants impact gene expression, with most mechanistic studies to date focused on the effects of genetic change on regulatory regions upstream of protein-coding sequence. By contrast, the role of RNA 3'-end processing in regulatory variation remains largely unknown, owing in part to the challenge of identifying functional elements in 3' untranslated regions. In this work, we conducted a genomic survey of transcript ends in lymphoblastoid cells from genetically distinct human individuals. Our analysis mapped the cis-regulatory architecture of 3' gene ends, finding that transcript end positio

SUBMITTER: Yoon OK 

PROVIDER: S-EPMC3420953 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature