Pharmacokinetics and tolerability of single-dose daptomycin in young infants.

ABSTRACT:

Background

Daptomycin is approved for the treatment of complicated skin and skin-structure infections and Staphylococcus aureus bacteremia. We sought to characterize daptomycin single-dose pharmacokinetics and tolerability in young infants.

Methods

Subjects < 120 days of age with suspected systemic infections were eligible for inclusion. Each subject was given a single 6 mg/kg intravenous dose of daptomycin. An average of 4 postdose concentrations per infant was obtained.

Results

Data from 20 infants are presented. Median gestational age at birth and postnatal age were 32 weeks (range: 23, 40) and 3 days (1, 85), respectively. The median area under the concentration curve at 24 hours, volume of distribution, total body clearance and half-life of daptomycin were 262.4

SUBMITTER: Cohen-Wolkowiez M 

PROVIDER: S-EPMC3421038 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature