Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS).

ABSTRACT:

Introduction

Adenocarcinoma in situ (AIS), formerly bronchioloalveolar carcinoma, is an uncommon subtype of lung adenocarcinoma and accounts for approximately 3% to 4% of lung cancers. Compared with other lung cancer histologies, AIS patients are less likely to be smokers, yet associations with other lung cancer risk factors and differences by sex have not been determined.

Methods

A total of 338 AIS patients and frequency-matched controls from the parent study (cases = 6039, controls = 2073) were included in these analyses. Odds ratios and 95% confidence intervals as estimates of the relative risk were obtained from multivariable unconditional logistic regression analyses.

Results

Risk of AIS was associated with ever smoking (OR = 2.7, 95% confidence intervals: 2.1, 3

SUBMITTER: Bracci PM 

PROVIDER: S-EPMC3421052 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature