Obesity phenotypes in midlife and cognition in early old age: the Whitehall II cohort study.

ABSTRACT:

Objective

To examine the association of body mass index (BMI) and metabolic status with cognitive function and decline.

Methods

A total of 6,401 adults (71.2% men), aged 39-63 years in 1991-1993, provided data on BMI (normal weight 18.5-24.9 kg/m(2), overweight 25-29.9 kg/m(2); and obese ≥30 kg/m(2)) and metabolic status (abnormality defined as 2 or more of 1) triglycerides ≥1.69 mmol/L or lipid-lowering drugs, 2) systolic blood pressure ≥130 mm Hg, diastolic blood pressure ≥85 mm Hg, or antihypertensive drugs, 3) glucose ≥5.6 mmol/L or medications for diabetes, and 4) high-density lipoprotein cholesterol <1.04 mmol/L for men and <1.29 mmol/L for women). Four cognitive tests (memory, reasoning, semantic, and phonemic fluency) were administered in 1997-1999, 2002-2004, and 20

SUBMITTER: Singh-Manoux A 

PROVIDER: S-EPMC3421151 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature