Promoter hypermethylation in sentinel lymph nodes as a marker for breast cancer recurrence.

ABSTRACT:

Purpose

Promoter methylation of tumor suppressor genes in histologically negative sentinel lymph nodes (HNSN) of early stage breast cancer patients has not been extensively studied. This study evaluates the methylation frequency and pattern in HNSN to determine if detection of hypermethylation of one or more genes is associated with an increased recurrence risk in node negative breast cancer.

Experimental design

In 1998, a prospective study of patients with early stage breast cancer and HNSN was initiated in order to correlate sentinel node analysis with clinical outcome. Nodal tissue was selected from 120 HNSN patients for methylation analysis in at least one and up to six sentinel nodes using a panel of nine genes. Corresponding primary breast tumors from 79 patients were

SUBMITTER: Carraway HE 

PROVIDER: S-EPMC3422075 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature