Possible association of the Plasmodium falciparum T1526C resa2 gene mutation with severe malaria.

ABSTRACT:

Background

Plasmodium falciparum exports proteins that remodel the erythrocyte membrane. One such protein, called Pf155/RESA (RESA1) contributes to parasite fitness, optimizing parasite survival during febrile episodes. Resa1 gene is a member of a small family comprising three highly related genes. Preliminary evidence led to a search for clues indicating the involvement of RESA2 protein in the pathophysiology of malaria. In the present study, cDNA sequence of resa2 gene was obtained from two different strains. The proportion of P. falciparum isolates having a non-stop T1526C mutation in resa2 gene was evaluated and the association of this genotype with severity of malaria was investigated.

Methods

Resa2 cDNAs of two different strains (a patient isolate and K1 culture adapte

SUBMITTER: Durand R 

PROVIDER: S-EPMC3422168 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature