Meta-analysis of general bacterial subclades in whole-genome phylogenies using tree topology profiling.

ABSTRACT: In the last two decades, a large number of whole-genome phylogenies have been inferred to reconstruct the Tree of Life (ToL). Underlying data models range from gene or functionality content in species to phylogenetic gene family trees and multiple sequence alignments of concatenated protein sequences. Diversity in data models together with the use of different tree reconstruction techniques, disruptive biological effects and the steadily increasing number of genomes have led to a huge diversity in published phylogenies. Comparison of those and, moreover, identification of the impact of inference properties (underlying data model, inference technique) on particular reconstructions is almost impossible. In this work, we introduce tree topology profiling as a method to compare already publish

SUBMITTER: Meinel T 

PROVIDER: S-EPMC3422217 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature