Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification.

ABSTRACT: Brain serotonin (5-HT) is implicated in a wide range of functions from basic physiological mechanisms to complex behaviors, including neuropsychiatric conditions, as well as in developmental processes. Increasing evidence links 5-HT signaling alterations during development to emotional dysregulation and psychopathology in adult age. To further analyze the importance of brain 5-HT in somatic and brain development and function, and more specifically differentiation and specification of the serotonergic system itself, we generated a mouse model with brain-specific 5-HT deficiency resulting from a genetically driven constitutive inactivation of neuronal tryptophan hydroxylase-2 (Tph2). Tph2 inactivation (Tph2-/-) resulted in brain 5-HT deficiency leading to growth retardation and persistent le

SUBMITTER: Gutknecht L 

PROVIDER: S-EPMC3422228 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature