Defining causative factors contributing in the activation of hedgehog signaling in diffuse large B-cell lymphoma.
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SUBMITTER: Ramirez E
PROVIDER: S-EPMC3422406 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Defining causative factors contributing in the activation of hedgehog signaling in diffuse large B-cell lymphoma.
Ramirez Elisa E Singh Rajesh R RR Kunkalla Kranthi K Liu Yadong Y Qu Changju C Cain Christine C Multani Asha S AS Lennon Patrick A PA Jackacky Jared J Ho Michael M Dawud Sity S Gu Jun J Yang Su S Hu Peter C PC Vega Francisco F
Leukemia research 20120717 10
Hedgehog (Hh) signaling pathway is activated in diffuse large B-cell lymphoma (DLBCL). Genetic abnormalities that explain activation of Hh signaling in DLBCL are unknown. We investigate the presence of amplifications of Hh genes that might result in activation of this pathway in DLBCL. Our data showed few extra copies of GLI1 and SMO due to chromosomal aneuploidies in a subset of DLBCL cell lines. We also showed that pharmacologic inhibition of PI3K/AKT and NF-κB pathways resulted in decreased e ...[more]
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