Genetics, environment, and diabetes-related end-stage renal disease in the Canary Islands.

ABSTRACT:

Aims

Type 1 and type 2 diabetes, complicated with renal disease, have a significantly higher incidence in the Canary Islands than in mainland Spain and other European countries. Present-day Canarian inhabitants consist of a mixed population with North African indigenous and European colonizer ancestors who have rapidly evolved from a rural to an urban life style. The aim of this work was to assess the possible role of genetic and environmental factors on diabetes-related end-stage renal disease incidence in the Canary Islands.

Results

For both types of diabetes there is an ethnic susceptibility increased by diabetes family history. Whereas the Y-chromosome does not play a significant role, mitochondrial DNA (mtDNA) haplogroup differences point to a maternal origin for this e

SUBMITTER: Gonzalez AM 

PROVIDER: S-EPMC3422557 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature