Discrete RNA libraries from pseudo-torsional space.

ABSTRACT: The discovery that RNA molecules can fold into complex structures and carry out diverse cellular roles has led to interest in developing tools for modeling RNA tertiary structure. While significant progress has been made in establishing that the RNA backbone is rotameric, few libraries of discrete conformations specifically for use in RNA modeling have been validated. Here, we present six libraries of discrete RNA conformations based on a simplified pseudo-torsional notation of the RNA backbone, comparable to phi and psi in the protein backbone. We evaluate the ability of each library to represent single nucleotide backbone conformations, and we show how individual library fragments can be assembled into dinucleotides that are consistent with established RNA backbone descriptors spanning f

SUBMITTER: Humphris-Narayanan E 

PROVIDER: S-EPMC3422622 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature