Common variation in fatty acid genes and resuscitation from sudden cardiac arrest.

ABSTRACT:

Background

Fatty acids provide energy and structural substrates for the heart and brain and may influence resuscitation from sudden cardiac arrest (SCA). We investigated whether genetic variation in fatty acid metabolism pathways was associated with SCA survival.

Methods and results

Subjects (mean age, 67 years; 80% male, white) were out-of-hospital SCA patients found in ventricular fibrillation in King County, WA. We compared subjects who survived to hospital admission (n=664) with those who did not (n=689), and subjects who survived to hospital discharge (n=334) with those who did not (n=1019). Associations between survival and genetic variants were assessed using logistic regression adjusting for age, sex, location, time to arrival of paramedics, whether the event was wit

SUBMITTER: Johnson CO 

PROVIDER: S-EPMC3422654 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature