Ontology highlight
ABSTRACT:
SUBMITTER: Kawahara M
PROVIDER: S-EPMC3422691 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Cancer cell 20120801 2
Homeobox domain-containing transcription factors are important regulators of hematopoiesis. Here, we report that increased levels of nonclustered H2.0-like homeobox (HLX) lead to loss of functional hematopoietic stem cells and formation of aberrant progenitors with unlimited serial clonogenicity and blocked differentiation. Inhibition of HLX reduces proliferation and clonogenicity of leukemia cells, overcomes the differentiation block, and leads to prolonged survival. HLX regulates a transcripti ...[more]