X-ray repair cross-complementing group 1 polymorphisms and hepatocellular carcinoma: a meta-analysis.

ABSTRACT:

Aim

To perform a systematic meta-analysis to investigate the association between X-ray repair cross-complementing group 1 (XRCC1) polymorphisms and hepatocellular carcinoma (HCC) risk.

Methods

Relevant studies extracted from PubMed, Embase, Wanfang, VIP and the Chinese National Knowledge Infrastructure databases up to March 2012 were included in the study. Stata software, version 11.0, was used for the statistical analysis. The odds ratios (ORs) and 95% confidence interval (CI) of the XRCC1 polymorphisms in HCC patients were analyzed and compared with healthy controls. The meta-analysis was performed using fixed-effect or random-effect methods, depending on the absence or presence of significant heterogeneity.

Results

Eleven studies with 2075 HCC cases and 2604 contro

SUBMITTER: Xie T 

PROVIDER: S-EPMC3422803 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature