Association of rs2072183 SNP and serum lipid levels in the Mulao and Han populations.

ABSTRACT:

Background

Niemann-pick C1-like 1 (NPC1L1) is a key protein for intestinal cholesterol transportation. Common single nucleotide polymorphisms (SNPs) in the NPC1L1 gene have been associated with cholesterol absorption and serum lipid levels. The present study was undertaken to explore the possible association of NPC1L1 rs2072183 1735 C > G SNP and several environmental factors with serum lipid levels in the Mulao and Han populations.

Methods

Genotyping of the rs2072183 SNP was performed in 688 subjects of Mulao and 738 participants of Han Chinese. The interactions between NPC1L1 1735 C > G polymorphism and several environmental factors on serum lipid phenotypes were tested using the factorial design covariance analysis after controlling for potential confounders.

Results</

SUBMITTER: Miao L 

PROVIDER: S-EPMC3422998 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature