Normal sulfation levels regulate spinal cord neural precursor cell proliferation and differentiation.

ABSTRACT:

Background

Sulfated glycosaminoglycan chains are known for their regulatory functions during neural development and regeneration. However, it is still unknown whether the sulfate residues alone influence, for example, neural precursor cell behavior or whether they act in concert with the sugar backbone. Here, we provide evidence that the unique 473HD-epitope, a representative chondroitin sulfate, is expressed by spinal cord neural precursor cells in vivo and in vitro, suggesting a potential function of sulfated glycosaminoglycans for spinal cord development.

Results

Thus, we applied the widely used sulfation inhibitor sodium chlorate to analyze the importance of normal sulfation levels for spinal cord neural precursor cell biology in vitro. Addition of sodium chlorate to spi

SUBMITTER: Karus M 

PROVIDER: S-EPMC3423038 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature