Double blockade of angiotensin II (AT(1) )-receptors and ACE does not improve weight gain and glucose homeostasis better than single-drug treatments in obese rats.

ABSTRACT:

Background and purpose

Combination therapies are becoming increasingly important for the treatment of high blood pressure. Little is known about whether double blockade of angiotensin II (AT(1) ) receptors and angiotensin-converting enzyme (ACE) exert synergistic metabolic effects.

Experimental approach

Spontaneously hypertensive rats were allowed to choose between palatable chocolate bars and standard chow and were simultaneously treated with the AT(1) blocker telmisartan (8 mg·kg(bw) (-1) ·day(-1) ), the ACE inhibitor ramipril (4 mg·kg(bw) (-1) ·day(-1) ) or a combination of the two (8 + 4 mg·kg(bw) (-1) ·day(-1) ) for 12 weeks.

Key results

Although food-dependent energy intake was increased by telmisartan and telmisartan + ramipril compared with ramipril or control

SUBMITTER: Miesel A 

PROVIDER: S-EPMC3423257 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature