Effects of rs7903146 variation in the Tcf7l2 gene in the lipid metabolism of three different populations.

ABSTRACT:

Background

TCF7L2 rs7903146 is an important genetic factor predicting type 2 diabetes (T2DM) which has also been linked to higher cardiovascular risk. To date, there is little information about the additional impact of this single nucleotide polymorphism (SNP) beyond glucose metabolism.

Methodology/principal findings

We studied whether rs7903146 influenced postprandial lipid metabolism in three different populations (healthy young men, metabolic syndrome (MetS) patients and elderly persons). Eighty-eight healthy males were submitted to a single saturated fatty acid-rich test meal. Additionally, 110 middle-aged MetS patients and 20 healthy elderly persons (≥ 65 years) were submitted to three different dietary models followed by test meals. Minor allele homozygotes for rs79031

SUBMITTER: Perez-Martinez P 

PROVIDER: S-EPMC3423356 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature