Risk factors associated with secondary sarcomas in childhood cancer survivors: a report from the childhood cancer survivor study.

ABSTRACT:

Purpose

Childhood cancer survivors have an increased risk of secondary sarcomas. To better identify those at risk, the relationship between therapeutic dose of chemotherapy and radiation and secondary sarcoma should be quantified.

Methods and materials

We conducted a nested case-control study of secondary sarcomas (105 cases, 422 matched controls) in a cohort of 14,372 childhood cancer survivors. Radiation dose at the second malignant neoplasm (SMN) site and use of chemotherapy were estimated from detailed review of medical records. Odds ratios (ORs) and 95% confidence intervals were estimated by conditional logistic regression. Excess odds ratio (EOR) was modeled as a function of radiation dose, chemotherapy, and host factors.

Results

Sarcomas occurred a median of 11

SUBMITTER: Henderson TO 

PROVIDER: S-EPMC3423483 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature