Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia?

ABSTRACT:

Background

Experimental changes in resting cerebral blood flow (CBF) affect task-related blood oxygenation level dependent (BOLD) responses. Since patients with schizophrenia have been shown to have abnormal resting CBF, we sought to determine whether differences between patients and healthy controls in resting CBF contribute to group differences in BOLD response.

Methods

BOLD images were acquired in nineteen patients and twenty healthy controls looking at photographs of faces, and resting CBF was measured by arterial spinning labeling. Resting CBF was then used to adjust group differences in task-related BOLD signal increases in linear models.

Results

Patients had different resting CBF from healthy controls in right basal ganglion and bilateral thalami. Associations

SUBMITTER: Liu J 

PROVIDER: S-EPMC3423495 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature