Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis.

ABSTRACT:

Background & aims

Innate and adaptive immune responses are regulated by cross talk between activation and inhibitory signals. Dysregulation of the inhibitory signal can lead to aberrant chronic inflammatory diseases such as the inflammatory bowel diseases (IBD). Little is known about negative regulation of innate intestinal immune activation. We examined the role of the inhibitory receptor paired immunoglobulin-like receptor B (PIR-B) in the regulation of macrophage function in innate intestinal immunity.

Methods

We examined the susceptibility of Pirb-/- and wild-type (WT) mice to dextran sodium sulfate (DSS)-induced colitis. We assessed proinflammatory cytokine release and mitogen-activated protein kinase (MAPK) and nuclear factor kappaB (NF-kappaB) activation in Pirb-/- an

SUBMITTER: Munitz A 

PROVIDER: S-EPMC3423916 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature