Potential for rabies control through dog vaccination in wildlife-abundant communities of Tanzania.

ABSTRACT: Canine vaccination has been successful in controlling rabies in diverse settings worldwide. However, concerns remain that coverage levels which have previously been sufficient might be insufficient in systems where transmission occurs both between and within populations of domestic dogs and other carnivores. To evaluate the effectiveness of vaccination targeted at domestic dogs when wildlife also contributes to transmission, we applied a next-generation matrix model based on contract tracing data from the Ngorongoro and Serengeti Districts in northwest Tanzania. We calculated corresponding values of R(0), and determined, for policy purposes, the probabilities that various annual vaccination targets would control the disease, taking into account the empirical uncertainty in our field data.

SUBMITTER: Fitzpatrick MC 

PROVIDER: S-EPMC3424251 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature