Effects of equine joint injury on boundary lubrication of articular cartilage by synovial fluid: role of hyaluronan.

ABSTRACT:

Objective

To compare equine synovial fluid (SF) from injured and control joints for cartilage boundary lubrication function; concentrations of the putative boundary lubricant molecules hyaluronan (HA), proteoglycan 4 (PRG4), and surface-active phospholipids (SAPLs); relationships between lubrication function and composition; and lubrication restoration by addition of HA.

Methods

Equine SF from normal joints, joints with acute injury, and joints with chronic injury were analyzed for boundary lubrication of normal articular cartilage (kinetic friction coefficient [μ(kinetic) ]). Equine SF samples were analyzed for HA, PRG4, and SAPL concentrations and HA molecular weight distribution. The effect of the addition of HA, of different concentrations and molecular weight, on the μ(

SUBMITTER: Antonacci JM 

PROVIDER: S-EPMC3424370 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature