An atlas of the Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions.

ABSTRACT: Epstein-Barr virus (EBV), which is associated with multiple human tumors, persists as a minichromosome in the nucleus of B lymphocytes and induces malignancies through incompletely understood mechanisms. Here, we present a large-scale functional genomic analysis of EBV. Our experimentally generated nucleosome positioning maps and viral protein binding data were integrated with over 700 publicly available high-throughput sequencing data sets for human lymphoblastoid cell lines mapped to the EBV genome. We found that viral lytic genes are coexpressed with cellular cancer-associated pathways, suggesting that the lytic cycle may play an unexpected role in virus-mediated oncogenesis. Host regulators of viral oncogene expression and chromosome structure were identified and validated, revealing a

SUBMITTER: Arvey A 

PROVIDER: S-EPMC3424516 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature