Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis.

ABSTRACT:

Background

Membrane-bound organelles are a defining feature of eukaryotic cells, and play a central role in most of their fundamental processes. The Rab G proteins are the single largest family of proteins that participate in the traffic between organelles, with 66 Rabs encoded in the human genome. Rabs direct the organelle-specific recruitment of vesicle tethering factors, motor proteins, and regulators of membrane traffic. Each organelle or vesicle class is typically associated with one or more Rab, with the Rabs present in a particular cell reflecting that cell's complement of organelles and trafficking routes.

Results

Through iterative use of hidden Markov models and tree building, we classified Rabs across the eukaryotic kingdom to provide the most comprehensive view of

SUBMITTER: Klopper TH 

PROVIDER: S-EPMC3425129 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature