High γ-radiation sensitivity is associated with increased gastric cancer risk in a Chinese Han population: a case-control analysis.

ABSTRACT: Hypersensitivity to radiation exposure has been suggested to be a risk factor for the development of several malignancies, but not including gastric cancer. In this case-control study, radiation sensitivity as measured by chromatid breaks per cell (b/c) was examined in cultured peripheral blood lymphocytes (PBLs) from 517 patients with gastric cancer and 525 healthy controls. Our results showed that b/c values were significantly higher in cases than in controls (Mean [SD], 0.47 [0.20] vs. 0.34 [0.17]; P<0.001). Using the 50(th) percentile value for controls (0.34 b/c) as the cutoff point, unconditional logistic regression analysis revealed that γ-radiation-sensitive individuals were at significantly higher risk for gastric cancer (adjusted odds ratio [OR] 2.01, 95% confidence interval [CI]

SUBMITTER: Dong H 

PROVIDER: S-EPMC3425539 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature