The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection.

ABSTRACT: Mucosotropic, high-risk human papillomaviruses (HPV) are sexually transmitted viruses that are causally associated with the development of cervical cancer. The most common high-risk genotype, HPV16, is an obligatory intracellular virus that must gain entry into host epithelial cells and deliver its double stranded DNA to the nucleus. HPV capsid proteins play a vital role in these steps. Despite the critical nature of these capsid protein-host cell interactions, the precise cellular components necessary for HPV16 infection of epithelial cells remains unknown. Several neutralizing epitopes have been identified for the HPV16 L2 minor capsid protein that can inhibit infection after initial attachment of the virus to the cell surface, which suggests an L2-specific secondary receptor or cofactor

SUBMITTER: Woodham AW 

PROVIDER: S-EPMC3425544 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature