Brain transcriptional responses to high-fat diet in Acads-deficient mice reveal energy sensing pathways.

ABSTRACT:

Background

How signals from fatty acid metabolism are translated into changes in food intake remains unclear. Previously we reported that mice with a genetic inactivation of Acads (acyl-coenzyme A dehydrogenase, short-chain), the enzyme responsible for mitochondrial beta-oxidation of C4-C6 short-chain fatty acids (SCFAs), shift consumption away from fat and toward carbohydrate when offered a choice between diets. In the current study, we sought to indentify candidate genes and pathways underlying the effects of SCFA oxidation deficiency on food intake in Acads-/- mice.

Methodology/principal findings

We performed a transcriptional analysis of gene expression in brain tissue of Acads-/- and Acads+/+ mice fed either a high-fat (HF) or low-fat (LF) diet for 2 d. Ingenuity Pathwa

SUBMITTER: Kruger C 

PROVIDER: S-EPMC3425564 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature