MRI abnormalities following febrile status epilepticus in children: the FEBSTAT study.

ABSTRACT:

Objective

The FEBSTAT study is a prospective study that seeks to determine the acute and long-term consequences of febrile status epilepticus (FSE) in childhood.

Methods

From 2003 to 2010, 199 children age 1 month to 5 years presenting with FSE (>30 minutes) were enrolled in FEBSTAT within 72 hours of the FSE episode. Of these, 191 had imaging with emphasis on the hippocampus. All MRIs were reviewed by 2 neuroradiologists blinded to clinical details. A group of 96 children with first simple FS who were imaged using a similar protocol served as controls.

Results

A total of 22 (11.5%) children had definitely abnormal (n = 17) or equivocal (n = 5) increased T2 signal in the hippocampus following FSE compared with none in the control group (p < 0.0001). Developmental abno

SUBMITTER: Shinnar S 

PROVIDER: S-EPMC3425848 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature