Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton.

ABSTRACT:

Background

Histone deacetylase-4 (Hdac4) is a class II histone deacetylase that inhibits the activity of transcription factors. In humans, HDAC4 deficiency is associated with non-syndromic oral clefts and brachydactyly mental retardation syndrome (BDMR) with craniofacial abnormalities.

Results

We identify hdac4 in zebrafish and characterize its function in craniofacial morphogenesis. The gene is present as a single copy, and the deduced Hdac4 protein sequence shares all known functional domains with human HDAC4. The zebrafish hdac4 transcript is widely present in migratory cranial neural crest (CNC) cells of the embryo, including populations migrating around the eye, which previously have been shown to contribute to the formation of the palatal skeleton of the early larva. E

SUBMITTER: DeLaurier A 

PROVIDER: S-EPMC3426487 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature