Functional divergence of gene duplicates - a domain-centric view.

ABSTRACT:

Background

Gene duplicates have been shown to evolve at different rates. Here we further investigate the mechanism and functional underpinning of this phenomenon by assessing asymmetric evolution specifically within functional domains of gene duplicates.

Results

Based on duplicate genes in five teleost fishes resulting from a whole genome duplication event, we first show that a Fisher Exact test based approach to detect asymmetry is more sensitive than the previously used Likelihood Ratio test. Using our Fisher Exact test, we found that the evolutionary rate asymmetry in the overall protein is largely explained by the asymmetric evolution within specific protein domains. Moreover, among cases of asymmetrically evolving domains, for the gene copy containing a fast evolving do

SUBMITTER: Khaladkar M 

PROVIDER: S-EPMC3426493 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature