Glycines: role in α-helical membrane protein structures and a potential indicator of native conformation.

ABSTRACT: Among the growing number of membrane protein structures in the Protein Data Bank, there are many transmembrane domains that appear to be native-like; at the same time, there are others that appear to have less than complete native-like character. Hence, there is an increasing need for validation tools that distinguish native-like from non-native-like structures. Membrane mimetics used in protein structural characterizations differ in numerous physicochemical properties from native membranes and provide many opportunities for introducing non-native-like features into membrane protein structures. One possible approach for validating membrane protein structures is based on the use of glycine residues in transmembrane domains. Here, we have reviewed the membrane protein structure database and

SUBMITTER: Dong H 

PROVIDER: S-EPMC3426646 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature