Phosphate starvation promotes swarming motility and cytotoxicity of Pseudomonas aeruginosa.

ABSTRACT: We investigated the transcriptional responses of Pseudomonas aeruginosa under phosphate-deficient (0.2 mM) conditions compared to phosphate sufficiency (1 mM). This elicited enormous transcriptional changes in genes related to phosphate acquisition, quorum sensing, chemotaxis, toxin secretion, and regulation. This dysregulation also led to increased virulence-associated phenotypes, including swarming motility and cytotoxicity.

SUBMITTER: Bains M 

PROVIDER: S-EPMC3426718 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature