Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus.

ABSTRACT: Many tumors are characterized by recurrent translocations between a tissue-specific gene and a proto-oncogene. The juxtaposition of the Ig heavy chain gene and Myc in Burkitt's lymphoma and in murine plasmacytoma is a classic example. Regulatory elements within the heavy chain constant region locus are required for Myc translocation and/or deregulation. However, many genes are regulated by cis-acting elements at distances up to 1,000 kb outside the locus. Such putative distal elements have not been examined for the heavy chain locus, particularly in the context of Myc translocations. We demonstrate that a transgene containing the Ig heavy chain constant region locus, inserted into five different chromosomal locations, can undergo translocations involving Myc. Furthermore, these translocati

SUBMITTER: Spehalski E 

PROVIDER: S-EPMC3427096 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature