Enantioselective cytotoxicity profile of o,p'-DDT in PC 12 cells.

ABSTRACT:

Background

The continued uses of dichlordiphenyltrichloroethane (DDT) for indoor vector control in some developing countries have recently fueled intensive debates toward the global ban of this persistent legacy contaminant. Current approaches for ecological and health risk assessment has ignored the chiral nature of DDT. In this study by employing an array of cytotoxicity related endpoints, we investigated the enantioselective cytotoxicity of o,p'-DDT.

Principal findings

we demonstrated for the first time that R-(-)-o,p'-DDT caused more neuron cell death by inducing more severe oxidative stress, which selectively imbalanced the transcription of stress-related genes (SOD1, SOD2, HSP70) and enzyme (superoxide dismutase and lactate dehydrogenase) activities, and greater cellul

SUBMITTER: Zhao M 

PROVIDER: S-EPMC3427172 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature