The hippocampus remains activated over the long term for the retrieval of truly episodic memories.

ABSTRACT: The role of the hippocampus in declarative memory consolidation is a matter of intense debate. We investigated the neural substrates of memory retrieval for recent and remote information using functional magnetic resonance imaging (fMRI). 18 young, healthy participants learned a series of pictures. Then, during two fMRI recognition sessions, 3 days and 3 months later, they had to determine whether they recognized or not each picture using the "Remember/Know" procedure. Presentation of the same learned images at both delays allowed us to track the evolution of memories and distinguish consistently episodic memories from those that were initially episodic and then became familiar or semantic over time and were retrieved without any contextual detail. Hippocampal activation decreased over tim

SUBMITTER: Harand C 

PROVIDER: S-EPMC3427359 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature