Hic-5 is required for fetal gene expression and cytoskeletal organization of neonatal cardiac myocytes.

ABSTRACT: Cardiac costameres link the extracellular matrix to the sarcomere at the z-disc and contain proteins such as integrins and other signaling molecules implicated in the regulation of pathological hypertrophy. Paxillin family members, hic-5 and paxillin, are scaffolding proteins associated with the integrin complex that have been shown to mediate numerous protein interactions in other cell types. While paxillin has been described in postnatal heart, hic-5 has not been identified. Our results provide evidence of hic-5 in neonatal cardiac myocytes co-localized with paxillin and alpha-actinin at the z-discs and the ends of actin filaments. Treatment with the hypertrophic agonist phenylephrine resulted in increased hic-5 expression while having no effect on paxillin levels. To see if increased hi

SUBMITTER: Yund EE 

PROVIDER: S-EPMC3427732 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature