Youth type 2 diabetes: insulin resistance, beta-cell failure, or both?

ABSTRACT:

Objective

This study evaluates insulin sensitivity, pancreatic beta-cell function (BCF), and the balance between the two in youth with type 2 diabetes and assesses the relationship of diabetes duration and HbA(1c) to insulin sensitivity and BCF.

Research design and methods

The subjects were 14 adolescents with type 2 diabetes and 20 obese control subjects of comparable age, BMI, body composition, and puberty. Insulin sensitivity was evaluated with a 3-h hyperinsulinemic (80 mU . m(-2) . min(-1)) euglycemic clamp. First-phase insulin secretion (FPIS) and second-phase insulin secretion (SPIS) were evaluated with a 2-h hyperglycemic (12.5 mmol/l) clamp. Fasting glucose rate of appearance was determined with the use of [6,6-(2)H(2)]glucose.

Results

Fasting glucose rate of

SUBMITTER: Gungor N 

PROVIDER: S-EPMC3428068 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature