Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer.

ABSTRACT: Crosstalk between the Notch and wingless-type MMTV integration site (WNT) signaling pathways has been investigated for many developmental processes. However, this negative correlation between Notch and WNT/β-catenin signaling activity has been studied primarily in normal developmental and physiological processes in which negative feedback loops for both signaling pathways are intact. We found that Notch1 signaling retained the capability of suppressing the expression of WNT target genes in colorectal cancers even when β-catenin destruction by the adenomatous polyposis coli (APC) complex was disabled. Activation of Notch1 converted high-grade adenoma into low-grade adenoma in an Apcmin mouse colon cancer model and suppressed the expression of WNT target genes in human colorectal cancer cell

SUBMITTER: Kim HA 

PROVIDER: S-EPMC3428081 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature