Continuous enteral and parenteral feeding each reduces heart rate variability but differentially influences monocyte gene expression in humans.

ABSTRACT: Enteral (EN) or parenteral (PN) nutrition is used to support critically ill patients until oral feeding resumes. Enteral nutrition is assumed preferable to PN, but the differential influence on immune function is not well defined. Autonomic nervous activity is known to influence innate immune responses, and we hypothesized that EN and PN could influence both autonomic signaling and gene activation in peripheral blood monocytes (PBMs). Ten subjects (aged 18-36 years) received continuous EN or PN for 72 h. Peripheral blood monocytes were isolated from whole blood before and after continuous feeding and were analyzed for gene expression using a microarray platform. Gene expression after feeding was compared from baseline and between groups. To measure autonomic outflow, subjects also underwen

SUBMITTER: Gale SC 

PROVIDER: S-EPMC3428199 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature