Renal function and genetic polymorphisms in pediatric heart transplant recipients.

ABSTRACT:

Background

Common genetic variations influence rejection, infection, drug metabolism, and side effect profiles after pediatric heart transplantation. Reports in adults suggest that genetic background may influence post-transplant renal function. In this multicenter study, we investigated the association of genetic polymorphisms (GPs) in a panel of candidate genes on renal function in 453 pediatric heart transplant recipients.

Methods

We performed genotyping for functional GPs in 19 candidate genes. Renal function was determined annually after transplantation by calculation of the estimated glomerular filtration rate (eGFR). Mixed-effects and Cox proportional hazard models were used to assess recipient characteristics and the effect of GPs on longitudinal eGFR and time to eGF

SUBMITTER: Feingold B 

PROVIDER: S-EPMC3428223 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature