Aversive and reinforcing opioid effects: a pharmacogenomic twin study.

ABSTRACT:

Background

The clinical utility of opioids is limited by adverse drug effects including respiratory depression, sedation, nausea, and pruritus. In addition, abuse of prescription opioids is problematic. Gaining a better understanding of the genetic and environmental mechanisms contributing to an individual's susceptibility to adverse opioid effects is essential to identify patients at risk.

Methods

A classic twin study paradigm provided estimates for the genetic and familial (genetic and/or shared environment) contribution to acute adverse and affective opioid responses, all secondary outcomes of a larger dataset. One hundred twenty-one twin pairs were recruited in a single occasion, randomized, double-blind, and placebo-controlled study. The μ-opioid receptor agonist alfent

SUBMITTER: Angst MS 

PROVIDER: S-EPMC3428265 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature