Creation of an open-access, mutation-defined fibroblast resource for neurological disease research.

ABSTRACT: Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and their subsequent differentiation into neurons and glia. Access to patient cell lines carrying the relevant mutations is a limiting factor for many centres wishing to pursue this research. We have therefore generated an open-access collection of fibroblast lines from patients carrying mutations linked to neurological disease. These cell li

SUBMITTER: Wray S 

PROVIDER: S-EPMC3428297 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature