Meal time shift disturbs circadian rhythmicity along with metabolic and behavioral alterations in mice.

ABSTRACT: In modern society, growing numbers of people are engaged in various forms of shift works or trans-meridian travels. Such circadian misalignment is known to disturb endogenous diurnal rhythms, which may lead to harmful physiological consequences including metabolic syndrome, obesity, cancer, cardiovascular disorders, and gastric disorders as well as other physical and mental disorders. However, the precise mechanism(s) underlying these changes are yet unclear. The present work, therefore examined the effects of 6 h advance or delay of usual meal time on diurnal rhythmicities in home cage activity (HCA), body temperature (BT), blood metabolic markers, glucose homeostasis, and expression of genes that are involved in cholesterol homeostasis by feeding young adult male mice in a time-restricti

SUBMITTER: Yoon JA 

PROVIDER: S-EPMC3428308 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature