Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis.

ABSTRACT:

Objective

To profile the abundance and diversity of subgingival oral microbiota in patients with never-treated, new-onset rheumatoid arthritis (RA).

Methods

Periodontal disease (PD) status, clinical activity, and sociodemographic factors were determined in patients with new-onset RA, patients with chronic RA, and healthy subjects. Multiplexed-454 pyrosequencing was used to compare the composition of subgingival microbiota and establish correlations between the presence/abundance of bacteria and disease phenotypes. Anti-Porphyromonas gingivalis antibody testing was performed to assess prior exposure to the bacterial pathogen P gingivalis.

Results

The more advanced forms of periodontitis were already present at disease onset in patients with new-onset RA. The subgingiva

SUBMITTER: Scher JU 

PROVIDER: S-EPMC3428472 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature