Oxidative condensations to form benzimidazole-substituted potassium organotrifluoroborates.

ABSTRACT: A library of benzimidazole-substituted potassium organotrifluoroborates was prepared via the condensation of various potassium formyl-substituted aryl- and heteroaryltrifluoroborates with aromatic 1,2-diamines under oxidative conditions. The efficient Suzuki-Miyaura cross-coupling of products thus formed to various aryl and heteroaryl bromides was achieved in good yields. The method allows the facile preparation of benzimidazole-containing triaromatic products in two steps from simple potassium formyl substituted aryl- or heteroaryltrifluoroborates.

SUBMITTER: Molander GA 

PROVIDER: S-EPMC3428750 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature