Childhood body mass index and adult pro-inflammatory and pro-thrombotic risk factors: data from the New Delhi birth cohort.

ABSTRACT:

Objective

Weight gain and growth in early life may influence adult pro-inflammatory and pro-thrombotic cardiovascular risk factors.

Methods

Follow-up of a birth cohort in New Delhi, India, whose weight and height were measured every 6 months until age 21 years. Body mass index (BMI) at birth, during infancy (2 years), childhood (11 years) and adulthood (26-32 years) and BMI gain between these ages were analysed in 886 men and 640 women with respect to adult fibrinogen, high-sensitivity C-reactive protein (hsCRP) and plasminogen activator inhibitor-1 (PAI-1) concentrations.

Results

All the pro-inflammatory/pro-thrombotic risk factors were higher in participants with higher adiposity. In women, BMI at birth and age 2 years was inversely related to fibrinogen (P = 0.002

SUBMITTER: Lakshmy R 

PROVIDER: S-EPMC3428891 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature