Maternally derived microduplications at 15q11-q13: implication of imprinted genes in psychotic illness.

ABSTRACT:

Objective

Rare copy number variants have been implicated in different neurodevelopmental disorders, with the same copy number variants often increasing risk of more than one of these phenotypes. In a discovery sample of 22 schizophrenia patients with an early onset of illness (10-15 years of age), the authors observed in one patient a maternally derived 15q11-q13 duplication overlapping the Prader-Willi/Angelman syndrome critical region. This prompted investigation of the role of 15q11-q13 duplications in psychotic illness.

Method

The authors scanned 7,582 patients with schizophrenia or schizoaffective disorder and 41,370 comparison subjects without known psychiatric illness for copy number variants at 15q11-q13 and determined the parental origin of duplications using methyl

SUBMITTER: Ingason A 

PROVIDER: S-EPMC3428917 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature