Cell-to-Cell Communication Circuits: Quantitative Analysis of Synthetic Logic Gates.

ABSTRACT: One of the goals in the field of synthetic biology is the construction of cellular computation devices that could function in a manner similar to electronic circuits. To this end, attempts are made to create biological systems that function as logic gates. In this work we present a theoretical quantitative analysis of a synthetic cellular logic-gates system, which has been implemented in cells of the yeast Saccharomyces cerevisiae (Regot et al., 2011). It exploits endogenous MAP kinase signaling pathways. The novelty of the system lies in the compartmentalization of the circuit where all basic logic gates are implemented in independent single cells that can then be cultured together to perform complex logic functions. We have constructed kinetic models of the multicellular IDENTITY, NOT, O

SUBMITTER: Hoffman-Sommer M 

PROVIDER: S-EPMC3429059 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature