Functionalized nanoporous silica for the removal of heavy metals from biological systems: adsorption and application.

ABSTRACT: Surface-functionalized nanoporous silica, often referred to as self-assembled monolayers on mesoporous supports (SAMMS), has previously demonstrated the ability to serve as very effective heavy metal sorbents in a range of aquatic and environmental systems, suggesting that they may be advantageously utilized for biomedical applications such as chelation therapy. Herein we evaluate surface chemistries for heavy metal capture from biological fluids, various facets of the materials' biocompatibility, and the suitability of these materials as potential therapeutics. Of the materials tested, thiol-functionalized SAMMS proved most capable of removing selected heavy metals from biological solutions (i.e., blood, urine, etc.) Consequentially, thiol-functionalized SAMMS was further analyzed to asse

SUBMITTER: Yantasee W 

PROVIDER: S-EPMC3429124 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature